> Strong alkaline condition
» No decomposition in NaOH
(solution in water /EtOH) at reflux temperature)
> Strong acidic condition
» No decomposition in conc. H2SO4 at room temperature
» Almost no hydrolysis in 100% H2SO4 at 100ºC (Ph-CF3 is hydrolyzed at 95ºC in same condition)
> Thermal stability
» Almost no decomposition at 400ºC (in a glass tube)
Lipophilicity(π) of substituent X
1) Umemoto, T.; Garrick, L. M.; Saito N. Beilstein J. Org. Chem. 2012, 8, 461.
2) Kosobokov, M.; Cui, B.; Balia, A.; Matsuzaki, K.; Tokunaga, E.; Saito N.; Shibata, N. Angew. Chem Int. Ed. Engl. 2016, 55, 10781.
3) Sheppard, W. A. J. Am. Chem. Soc. 1962, 84. 3072.
4) a) Bowden, R. D.; Comina, P. J.; Greenhall, M. P.; Kariuki, B. M.; Loveday, A.; Philip D. Tetrahedron 2000, 56, 3399.
b) Kirsch, P.; Bremer, M.; Heckmeier, M.; Tarumi, K. Angew. Chem Int. Ed. Engl. 1999, 38, 1989.
5) Kirsch, P. Modern Fluoroorganic Chemistry. Weinheim, Germany: Wiley-VCH 2004, 146.
6) Westphal, M. V.; Wolfstädter, B. T.; Plancher, J. M.; Gatfield, J.; Carreira, E. M. Chem. Med. Chem. 2015, 10, 461.
CONTACT US
The data is not available online. Please contact through this form so that wen can answer as soon as possible. Thank you!
The data is not available online. Please contact through this form so that wen can answer as soon as possible. Thank you!
Update your browser to view this website correctly. Update my browser now